color test

Rapid point-of-care testing for multiple diseases from a drop of blood

March 6, 2013

DNAzyme catalyst combined with gold nanoparticles (GNPs) provides a simple, sensitive colorimetric parallel assay for various infectious diseases (credit: Kyryl Zagorovsky and Warren C. W. Chan/Angewandte Chemie)

A diagnostic system using DNA powder and gold nanoparticles being developed by scientists at the University of Toronto’s Institute of Biomaterials and Biomedical Engineering could provide rapid point-of-care diagnosis of the world’s leading infectious diseases in the near future.

BBME PhD student Kyryl Zagorovsky has developed a rapid diagnostic biosensor that will allow technicians to test for multiple diseases at the same time with one small sample, and with high accuracy and sensitivity. The biosensor relies upon gold nanoparticles, which change color.

Quantitative PCR (qPCR) is the method of choice, because it includes an enzymatic signal amplification step to achieve highly sensitive and specific detection of genetic…

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