Researchers at Northeastern University in Boston have developed a gene therapy approach that may one day stop Parkinson’s disease (PD) in it tracks, preventing disease progression and reversing its symptoms

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Glial cell derived neurotrophic factor structure (credit: Wikimedia Commons)

http://experimentalbiology.org/EB/pages/default.aspx?splashpage=1

A noninvasive avenue for Parkinson’s disease gene therapy

Nanoparticles bypass the blood-brain barrier to treat Parkinson’s disease
April 26, 2013

Researchers at Northeastern University in Boston have developed a gene therapy approach that may one day stop Parkinson’s disease (PD) in it tracks, preventing disease progression and reversing its symptoms.

The novelty of the approach lies in the nasal route of administration and nanoparticles containing a gene capable of rescuing dying neurons in the brain.


Parkinson’s is a devastating neurodegenerative disorder caused by the death of dopamine neurons in a key motor area of the brain, the substantia nigra (SN). Loss of these neurons leads to the characteristic tremor and slowed movements of PD, which get increasingly worse with time.

Currently, more than 1% of the population over age 60 has PD and approximately 60,000 Americans are newly diagnosed every…

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