Novartis First-Generation Lung Cancer Drug Tweaked To Reduce Potential Side Effects

New Drug Approvals

Structures of anaplastic lymphoma kinase inhibitors
Novartis’ first-generation inhibitor of the enzyme anaplastic lymphoma kinase (TAE684, left) formed potentially harmful protein adducts in the body. To reduce side effects, chemists moved the position of a troublesome nitrogen to make the current version of the drug (LDK378, right).
Credit: J. Med. Chem.
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